| ncRNA name | hsa-miR-328 |
| ncRNA Category | miRNA |
| Disease name | myopia |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | immunocytochemistry, transfection, WST-1 assay, EdU proliferation assay, qPCR, Western blot |
| Expression pattern | up-regulated |
| Functional description | Over-expression of miR-328 is a risk for myopia. miR-328 dose-dependently increased HOXA9 expression in ARPE-19 and mouse primary RPE cells. Based on the human, animal and cellular data, the transcription factor HOXA9 may promote the expression of pro-myopia genes and RPE proliferation, which eventually contribute to myopia development. |
| PubMed ID | 30674274 |
| Year | 2019 |
| Title | HOXA9 is a novel myopia risk gene. |
| Drug-related ncRNA | NO |
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